周如鸿

人物经历

教育经历

工作经历

周如鸿教授于2011年当选美国科学促进会会士(AAAS Fellow)，美国物理学会会士(APS Fellow)，并于2012年入选IBM全球八大研究院“将对IBM，对世界，可能产生最重大影响”的五名科学家之一。周如鸿教授同时担任美国分子科学领域顶尖的Telluride科学研究中心董事会的董事（Board of Directors），和美国芝加哥大学多尺度科学中心的科学顾问（Scientific Advisory Board）。

现任浙江大学求是讲席教授，生命科学院院长，上海高等研究院院长，科技部十四五“生物大分子与微生物”专家组成员，哥伦比亚大学化学系兼职教授。曾任IBM Watson 研究院软物质科学系主任，IBM蓝色基因计划生命科学首席科学家，杰出研究员。[1]

在分子动力学模拟蛋白质结构，功能，以及动态过程、纳米尺度水的生物效应、以及纳米颗粒与生物分子的相互作用等研究领域成就显著。拥有或已申请14项美国专利。在权威学术刊物发表学术论文102篇，SCI引用3200余次。应邀在世界各地大学、研究机构和国际学术会议上做邀请报120余次，是期刊《Nanoscale》、《Current Physical Chemistry》客座主编，也是 《Current Bioinformatics》等6家国际期刊的编委。

代表论文

1. R. H. Zhou, X. Huang, C. Margulius and B. J. Berne, Hydrophobic Collapse in Multi-domain Protein Folding, Science, 305, 1605-1609, 2004

2. P. Liu, X. Huang, R. H. Zhou and B. J. Berne, Observation of a dewetting transition in the collapse of melittin tetramer, Nature, 437, 159-162, 2005

3. L. Cong, R. H. Zhou, Y. C. Kuo, M. Cunniff, and F. Zhang, Comprehensive Interrogation of Natural TALE DNA Binding Modules and Transcriptional Repressor Domains, Nature Commun. 3, 968, 2012

4. Z. Xia, P. Clark, T. Huynh, P. Loher, Y. Zhao, H.W. Chen, P. Y. Ren, I. Rigoutsos, and R. H. Zhou, Molecular dynamics simulations of Ago silencing complexes reveal a large repertoire of admissible ‘seed-less’ targets, Scientific Reports, 2, 569, 2012

5. S. G. Kang, G. Q. Zhou, P. Yang, Y. Liu, B. Y. Sun, T. Huynh, H. Meng, L. Zhao, G. M. Xing, C. Y. Chen, Y. L. Zhao, R. H. Zhou, Molecular Mechanism of Pancreatic Tumor Metastases Inhibition by Metallofullerenol Gd@C82(OH)22: Implication for de novo Design of Nanomedicine, Proc. Natl. Acad. Sci., 109, in press, 2012

6. C. Ge, J. F. Du, L. Zhao, L. Wang, Y. Liu, D. H. Li, Y. Yang, R. H. Zhou, Y. L. Zhao, Z. F. Chai, C. Y. Chen, Binding of human serum proteins on single-wall carbon nanotubes reduces cytotoxicity, Proc. Natl. Acad. Sci, 108, 16968-16973, 2011 (featured article)

7. P. Das, J. A. King, and R. H. Zhou, Aggregation of ?D-Crystallin Associated with Human Cataracts via Domain Swapping at the C-terminal ?-strands, Proc. Natl. Acad. Sci. 108, 10514-10519, 2011 (featured article)

8. Y. Tu, P. Xiu, R. Wan, J. Hu, R. H. Zhou and H. Fang, Water-mediated signal multiplication with Y-shaped carbon nanotubes, Proc. Natl. Acad. Sci. 106, 18120-18124, 2009

9. L. Hua, R. H. Zhou, D. Thirumalai, B. J. Berne, Urea denaturation by stronger dispersion interactions with proteins than water implies a 2-stage unfolding, Proc. Natl. Acad. Sci., 105, 16928-16933, 2008

10. J. Li, X. Gong, H. Lu, D. Li, H. Fang and R. H. Zhou, Electrostatic Gating of a Nanometer Water Channel, Proc. Natl. Acad. Sci., 104, 3687-3692, 2007

11. R. H. Zhou, M. Eleftheriou, A. Royyuru, B. J. Berne, Destruction of long-range interactions by a single mutation in lysozyme, Proc. Natl. Acad. Sci., 104, 5824-5829, 2007

12. R. H. Zhou, Trp-cage: Folding Free Energy Landscape in Explicit Water, Proc. Natl. Acad. Sci., 100, 13280， -13285, 2003

13. R. H. Zhou and B. D. Silverman, Detecting native protein folds among large decoy sets with hydrophobic moments profiling, Proc. Paci. Symp. Biocomp. 2002, Eds. R. B. Altman, A. K. Dunker, L. Hunter, K. Lauderdale and T. E. Klein, p673-684, World Scientific, Singapore, 2002

14. R. H. Zhou, B. J. Berne and R. Germain, Free energy landscape of a beta-hairpin folding in explicit water, Proc. Natl. Acad. Sci. 98, 14931-14936, 2001

获奖情况

1. CAREER Award for Researchers “most likely to have the greatest scientific impact for IBM and the world” (at most five scientists chosen each year among eight IBM Labs worldwide), IBM Research, May, 2012

2. IBM Outstanding Innovation Award (OIA), IBM Corp. 2012

3. IBM Research Division Award, IBM Research (2012)

4. William E. Schiesser Lecture, Lehigh University, April 2012

5. Elected to AAAS Fellow (American Association of Advancement of Science), 2011

6. Elected to APS Fellow (American Physical Society), 2011

7. Part of the IBM BlueGene Team who won 2009 National Medal on Innovation and Technology (presented by President Obama), 2009

8. IBM Invention Plateau Achievement Award, IBM Corporation (2009)

9. IBM Outstanding Technical Achievement Award (OTAA, the highest technical award of IBM), IBM Corp. (2008)

10. IBM Outstanding Technical Achievement Award (OTAA), IBM Corp. (2005)

11. IBM Research Division Award, IBM Research (2005)

12. IBM Invention Plateau Achievement Award, IBM Corporation (2004)

13. IBM Invention Achievement Award, IBM Corporation (2002)

14. The Hammett Award for Best Ph.D. Graduates, Columbia University (1997)

15. ACS Award on Computational Chemistry (DEC Award), American Chemical Society (1995)

16. Faculty Fellowship, Columbia University (1994-1997)

17. Second Prize, Research in Science & Technology, China Ministry of Education (1993)

18. Best Paper Award for Outstanding Research, Zhejiang University (1993)

19. Award for Outstanding Research, Zhejiang University (1992)

知识产权

1. Bruce J. Berne and Ruhong Zhou, Fast methods for simulating biomolecular systems with long-range electrostatic interactions by molecular dynamics, US patent No. 5,915,230, Jun 22, 1999

2. Ruhong Zhou, Huafeng Xu, Ed Harder, and Bruce J. Berne, System and Method for Molecular Dynamics Simulation , US patent, No. 7,096,167 B2, August 22, 2006

3. Prasanna Athma, Ajay Royyuru, David Silverman and Ruhong Zhou, Method and apparatus for protein structure analysis, US Patent, No. 7,499,805, March 3, 2009

4. Ruhong Zhou, David Silverman, Ajay Royyuru, and Prasanna Athma, Hydrophobic Moment of Multi-domain Proteins, United States, US patent No. 7,877,214, Jan, 25, 2011

5. Ruhong Zhou, David Silverman, Ajay Royyuru, and Prasanna Athma, Hydrophobic Dipole Orientational Analysis for Multi-domain Protein Structures, US patent No. 8,010,332, Jan, 2012

6. Ruhong Zhou, and David Silverman, Method and Apparatus for Protein Structure Analysis, US patent filed (IBM Docket No. YOR920020224US1), Nov. 15, 2002

7. David Silverman, Ruhong Zhou and Ajay Royyuru, Hydrophobic Fourier Transform for Protein Structure Prediction Validation, US patent search (IBM Docket No. YOR820030692), September, 2003

8. Laxmi Parida and Ruhong Zhou, Pattern Discovery Analysis for Protein Folding Trajectories, US patent search (IBM Docket No. YOR820040227), April, 2004

9. Laxmi Parida and Ruhong Zhou, Clustering of Multidimentional Real-valued Data Using Signature Patterns, US patent (IBM Docket No. YOR820040321), May, 2004

10. Laxmi Parida and Ruhong Zhou, Visual Analysis of Pattern Landscape Animation, US patent (IBM Docket No. YOR920060233US1), March, 2006

11. Zhen Xia and Ruhong Zhou, Prediction of Influenza A Virus' Genetic Evolution with a Mutual Information Based Site Transition Network, IBM Docket No. YOR820090279, July 1, 2009

12. Payel Das and Ruhong Zhou, A biomimetic nano-pump for automatic separation of urea from water, DISCLOSURE NO. YOR820101155, November 12, 2010

13. Zhen Xia, Tien Hyunh, and Ruhong Zhou, Weighted mutual information method and automatic web server for influenza genetic variation prediction, DISCLOSURE NO. YOR820101065, October 18, 2010

14. James Kozloski, Cliff Pickover, Jacinta Wubben and Ruhong Zhou, System and Method for Competitive Binding of Sequence Annotations and Analysis Tools to Sequences in a Biological Data Repository, YOR820110975, October, 2011

15. Binquan Luan and Ruhong Zhou, Base-by-base Ratcheting DNA in a Y-shaped Carbon Nanotube, YOR820120589, May, 2012

16. Binquan Luan and Ruhong Zhou, Nanopore-Based Sensors for Detecting Nanotoxicity of a Carbon Nanotube to Proteins, YOR820120951, July, 2012

参考资料

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[1]周如鸿.浙江大学. [2022-01-15].

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